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MacroGenics issued a press release on May 19, 2021 “announc[ing] preliminary safety and anti-tumor activity data from the Company’s ongoing Phase 1 clinical trial of MGC018”, an “investigational antibody drug conjugate (ADC) . . . designed to deliver a DNA alkylating duocarmycin payload to both dividing and non-dividing cells in a B7-H3 dependent manner.” MacroGenics reported that “at least one treatment-related adverse event was experienced by 27 of 29 patients (93%)” and “[a]t 4.0 mg/kg, one patient developed a dose-limiting toxicity manifested by Grade 3 fatigue that lasted for more than 72 hours and as previously reported, a Grade 4 neutropenia occurred in a patient in the 2.0 mg/kg cohort.” among other data.