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Curis issued a press release on June 11, 2021 “announc[ing] updated data from its ongoing Phase 1/2 open-label, single arm, dose escalation and expansion trial of CA-4948, a novel, small molecule IRAK4 kinase inhibitor, in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) at the European Hematology Association 2021 Virtual Congress (EHA). “ Specifically, Curis stated that it had “concluded 300mg BID is the optimal dose to take into Phase 2 studies” after the 500 mg and 400 mg versions of the drug showed dose-limited toxicities.“
Curis’s stock price fell $4.67 per share, or 36.83%, on this news, to close at $8.01 per share on June 11, 2021.